Mark A Febbraio Selected Research

BGP 15

1/2023	Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
1/2018	Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.
12/2016	BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.
12/2014	The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
6/2014	Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.
4/2012	Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.
1/2011	Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts.

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Mark A Febbraio Research Topics

Disease

44	Insulin Resistance 11/2021 - 04/2003
39	Obesity 01/2023 - 09/2002
25	Inflammation (Inflammations) 01/2023 - 01/2003
20	Type 2 Diabetes Mellitus (MODY) 02/2024 - 09/2002
11	Metabolic Diseases (Metabolic Disease) 12/2021 - 04/2008
11	Glucose Intolerance 01/2020 - 06/2007
8	Weight Gain 10/2019 - 09/2013
6	Neoplasms (Cancer) 02/2024 - 01/2012
6	Body Weight (Weight, Body) 01/2020 - 12/2009
6	Atherosclerosis 01/2018 - 09/2002
5	Fatty Liver 03/2021 - 03/2015
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 12/2006
4	Heart Failure 01/2015 - 04/2010
3	Fibrosis (Cirrhosis) 01/2022 - 12/2016
3	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 12/2009
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 11/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 06/2017
2	Hyperinsulinism (Hyperinsulinemia) 10/2019 - 02/2008
2	Chronic Disease (Chronic Diseases) 12/2017 - 04/2012
2	Infarction (Infarctions) 10/2017 - 06/2011
2	Myocardial Infarction 10/2017 - 04/2010
2	Hyperglycemia 06/2017 - 02/2008
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 12/2016 - 04/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2013 - 12/2009
2	Hypertrophy 06/2012 - 04/2012
2	Weight Loss (Weight Reduction) 01/2011 - 05/2006
2	Fatigue 06/2003 - 09/2002
1	Bipolar Disorder (Manic Depressive Psychosis) 09/2023
1	Liver Diseases (Liver Disease) 05/2023
1	Fructose Intolerance (Intolerance, Fructose) 12/2021
1	Non-alcoholic Fatty Liver Disease 03/2021
1	Alcoholic Fatty Liver 10/2020

Drug/Important Bio-Agent (IBA)

30	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 09/2002
23	LipidsIBA 10/2021 - 05/2006
22	Insulin (Novolin)FDA Link 01/2018 - 09/2003
19	Interleukin-6 (Interleukin 6)IBA 01/2023 - 09/2002
12	CytokinesIBA 01/2021 - 01/2003
12	Fatty Acids (Saturated Fatty Acids)IBA 10/2020 - 05/2006
9	Proteins (Proteins, Gene)FDA Link 01/2018 - 07/2007
8	Ciliary Neurotrophic Factor (CNTF)IBA 10/2019 - 05/2006
7	BGP 15IBA 01/2023 - 01/2011
6	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2014 - 09/2003
6	CeramidesIBA 06/2014 - 05/2006
5	LeptinIBA 10/2019 - 08/2006
5	JNK Mitogen-Activated Protein KinasesIBA 01/2016 - 05/2006
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2014 - 04/2003
5	Triglycerides (Triacylglycerol)IBA 06/2014 - 09/2003
4	LigandsIBA 01/2021 - 04/2007
4	HSP72 Heat-Shock ProteinsIBA 01/2018 - 09/2003
4	DiglyceridesIBA 05/2015 - 12/2006
4	InterleukinsIBA 06/2014 - 04/2003
3	phosphatidylethanolamineIBA 03/2021 - 05/2015
3	Nonesterified Fatty Acids (NEFA)IBA 03/2021 - 05/2006
3	FollistatinIBA 01/2020 - 01/2011
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 12/2005
3	Phosphotransferases (Kinase)IBA 01/2016 - 02/2008
3	AMP-Activated Protein KinasesIBA 09/2013 - 05/2006
3	Messenger RNA (mRNA)IBA 04/2010 - 09/2003
3	AntioxidantsIBA 10/2009 - 09/2003
3	EnzymesIBA 10/2009 - 03/2009
2	CollagenIBA 01/2022 - 12/2016
2	FructoseIBA 12/2021 - 10/2020
2	Phospholipids (Phosphatides)FDA LinkGeneric 03/2021 - 05/2015
2	Phosphatidylcholines (Phosphatidylcholine)IBA 03/2021 - 05/2015
2	Phosphatidylinositols (Phosphatidylinositol)IBA 12/2020 - 04/2010
2	Therapeutic UsesIBA 01/2020 - 10/2019
2	Membrane LipidsIBA 05/2018 - 01/2011
2	CholesterolIBA 01/2018 - 01/2011
2	Amyloid (Amyloid Fibrils)IBA 01/2018 - 03/2011
2	salicylhydroxamic acid (SHAM)IBA 01/2018 - 03/2009
2	AntigensIBA 12/2017 - 01/2016
2	HDL LipoproteinsIBA 10/2017 - 04/2009
2	AdiponectinIBA 01/2017 - 01/2009
2	MyokinesIBA 10/2016 - 04/2012
2	Interleukin-18 (Interleukin 18)IBA 01/2016 - 09/2013
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2012 - 03/2011
2	MyostatinIBA 06/2012 - 04/2012
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2012 - 12/2009
2	Serine (L-Serine)FDA Link 01/2012 - 03/2011
2	Apolipoproteins E (ApoE)IBA 09/2011 - 06/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2009 - 10/2008
2	ThiazolidinedionesIBA 07/2007 - 06/2007
2	CarbohydratesIBA 08/2006 - 09/2002
1	Metformin (Glucophage)FDA LinkGeneric 02/2024
1	Small Nuclear RNA (snRNA)IBA 05/2023
1	MonosaccharidesIBA 12/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2020
1	TensinsIBA 12/2020
1	Vitamin E FDA LinkGeneric 06/2020
1	Pioglitazone (Actos)FDA Link 06/2020
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2020
1	Activins (Activin)IBA 01/2020
1	Sucrose (Saccharose)IBA 01/2020
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020
1	GuanosineIBA 01/2019

Therapy/Procedure

14	Therapeutics 02/2024 - 07/2007
2	Glycemic Control 01/2020 - 09/2015
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/2021